Title: Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation
Authors: Zhang, Xinying ×
Qu, Yingying
Fan, Xuesen
Bores, C
Feng, Dong
Andrei, Graciela
Snoeck, Robert
De Clercq, Erik
Loiseau, Philippe M #
Issue Date: Aug-2010
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:29 issue:8 pages:616-627
Abstract: A novel and highly efficient one-pot three-component synthesis of alpha-aminophosphonates under neat condition was developed. By employing this method, hybrid compounds of aminophosphonate with pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2'-deoxyuridine, aniline and dimethyl phosphite. The antiviral and antileishmanial activities of these novel hybrid compounds were also studied but none were found to be active.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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