Temporal dynamics of spontaneous MEG activity in brain networks
de Pasquale, Francesco × Della Penna, Stefania Snyder, Abraham Z Lewis, Christopher Mantini, Dante Marzetti, Laura Belardinelli, Paolo Ciancetta, Luca Pizzella, Vittorio Romani, Gian Luca Corbetta, Maurizio #
Natl acad sciences
Proceedings of the national academy of sciences of the united states of america vol:107 issue:13 pages:6040-6045
Functional MRI ( fMRI) studies have shown that low-frequency (<0.1 Hz) spontaneous fluctuations of the blood oxygenation level dependent ( BOLD) signal during restful wakefulness are coherent with-in distributed large-scale cortical and subcortical networks (resting state networks, RSNs). The neuronal mechanisms underlying RSNs remain poorly understood. Here, we describe magnetoencephalo-graphic correspondents of two well-characterized RSNs: the dorsal attention and the default mode networks. Seed-based correlation mapping was performed using time-dependent MEG power reconstructed at each voxel within the brain. The topography of RSNs computed on the basis of extended (5 min) epochs was similar to that observed with fMRI but confined to the same hemisphere as the seed region. Analyses taking into account the nonstationarity of MEG activity showed transient formation of more complete RSNs, including nodes in the contralateral hemisphere. Spectral analysis indicated that RSNs manifest in MEG as synchronous modulation of band-limited power primarily within the theta, alpha, and beta bands-that is, in frequencies slower than those associated with the local electrophysiological correlates of event-related BOLD responses.