Title: Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
Authors: Norrmén, Camilla ×
Vandevelde, Wouter
Ny, Annelii
Saharinen, Pipsa
Gentile, Massimiliano
Haraldsen, Guttorm
Puolakkainen, Pauli
Lukanidin, Eugene
Dewerchin, Mieke
Alitalo, Kari
Petrova, Tatiana V #
Issue Date: Jan-2010
Publisher: W.B. Saunders
Series Title: Blood vol:115 issue:4 pages:906-9
Abstract: The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin beta1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo, and show that it plays an important role in the maintenance of lymphatic vessel integrity in Xenopus tadpoles.
ISSN: 0006-4971
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Vesalius Research Centre (-)
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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