Title: Optimizing administration of epidermal growth factor receptor-targeted agents in the treatment of colorectal cancer
Authors: Van Cutsem, Eric # ×
Issue Date: Oct-2007
Series Title: Clinical colorectal cancer vol:6 Suppl 2 pages:S60-S65
Abstract: The monoclonal antibodies against the epidermal growth factor receptor (EGFR) are active in patients with metastatic colorectal cancer (CRC; mCRC). This activity has been shown initially in irinotecan- and chemotherapy-refractory mCRC. The correlation of rash after EGFR inhibitors and activity has led to the concept of the dose until rash study. Clinical trials evaluating this concept are ongoing. However, many unresolved challenges remain regarding this question. New challenges include the development of the most optimal schedule of the EGFR inhibitors and the evaluation of their role in less advanced stages and in the preoperative treatment of liver metastases of CRC.
ISSN: 1533-0028
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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