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Title: Influence of an estrone-desulfating intestinal flora on the enterohepatic circulation of estrone-sulfate in rats
Authors: Van Eldere, Johan ×
Parmentier, Guido
Robben, Johan
Eyssen, Hendrik #
Issue Date: Feb-1987
Publisher: Pergamon-elsevier science ltd
Series Title: Journal of steroid biochemistry vol:26 issue:2 pages:235-9
Abstract: The fecal and urinary excretion of orally administered [4-14C]estrone-3-sulfate was studied in germfree (GF) rats, conventional (CV) rats and gnotobiotic rats selectively associated with estrone-desulfating and/or cecal-volume reducing microorganisms. The time required to excrete 50% of the total label recovered (t 1/2) was 22 h in CV rats vs 32 h in GF rats. Gnotobiotic rats selectively associated with a cecal volume-reducing flora (CRF rats) excreted the label even faster (t 1/2 = 13 h) than CV rats. Association of GF rats as well as CRF rats with estrone-desulfating microorganisms (termed S1 + S2 + R9 rats and CRF + S1 + S2 + R9 rats, respectively) led to a slower excretion of labeled products (t 1/2 = 38 h in S1 + S2 + R9 rats and t 1/2 = 27 h in CFR + S1 + S2 + R9 rats). Intestinal microbial desulfation also increased the relative part of the urinary excretion from 4% in GF rats to 8% in S1 + S2 + R9 rats and from 3% in CRF rats to 9% in CFR + S1 + S2 + R9 rats. We conclude that intestinal microbial desulfation enhances the enterohepatic circulation of orally administered estrone-3-sulfate.
ISSN: 0960-0760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
Laboratory of Clinical Bacteriology and Mycology
Biochemistry, Molecular and Structural Biology Section
Laboratory for Experimental and Clinical Microbiology (-)
× corresponding author
# (joint) last author

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