Title: Lysozyme inhibitor conferring bacterial tolerance to invertebrate type lysozyme
Authors: Van Herreweghe, Joris
Vanderkelen, Lise
Callewaert, Lien
Aertsen, Abram
Compernolle, Griet
Declerck, Paul
Michiels, Christiaan # ×
Issue Date: Apr-2010
Publisher: Birkhäuser Verlag
Series Title: Cellular and Molecular Life Sciences vol:67 issue:7 pages:1170-1188
Abstract: Invertebrate (I-) type lysozymes, like all other known lysozymes, are dedicated to the hydrolysis of peptidoglycan, the major bacterial cell wall polymer, thereby contributing to the innate immune system and/or digestive system of invertebrate organisms. Bacteria on the other hand have developed several protective strategies against lysozymes, including the production of periplasmic and/or membrane-bound lysozyme inhibitors. The latter have until now only been described for chicken (C-) type lysozymes. We here report the discovery, purification, identification and characterization of the first bacterial specific I-type lysozyme inhibitor from Aeromonas hydrophila, which we designate PliI (periplasmic lysozyme inhibitor of the I-type lysozyme). PliI has homologs in several proteobacterial genera and contributes to I-type lysozyme tolerance in A. hydrophila in the presence of an outer membrane permeabilizer. These and previous findings on C-type lysozyme inhibitors suggest that bacterial lysozyme inhibitors may have an important function, for example, in bacteria-host interactions.
ISSN: 1420-682X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
Centre for Food and Microbial Technology
× corresponding author
# (joint) last author

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