Two imported cases of Penicillium marneffei infection in Belgium
Depraetere, K × Colebunders, R Ieven, M De Droogh, E Pelgrom, Y Hauben, Esther Van Marck, E Devroey, C #
Acta clinica belgica
Acta clinica belgica vol:53 issue:4 pages:255-258
Two imported cases of Penicillium marneffei infection in Belgium are reported. Both patients are Thai women co-infected with HIV. P. marneffei infection should be suspected in immunocompromised patients originating or travelling from South-East Asia with unexplained fever (>38 degrees C), weight loss, a generalised lymphadenopathy, hepatomegaly, splenomegaly, skin lesions, cough and anaemia. Diagnosis is made by culture and/or histopathological examination. Mild to moderate infections are treated with itraconazole 400 mg/day as first choice. Amphotericin B parenteral therapy may be required for seriously ill patients. Maintenance therapy with itraconazole 200 mg/day is necessary to prevent relapses.