Title: Binding of biotin to hepatitis B surface antigen: a possible pitfall in immunohistochemistry
Authors: van den Oord, Joost ×
Facchetti, F
de Wolf-Peeters, C
Desmet, V J #
Issue Date: Apr-1989
Series Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol:37 issue:4 pages:551-4
Abstract: We report on the binding of biotin, and hence of biotinylated antibodies and lectins, to ground glass hepatocytes and liver cell membranes in chronic hepatitis B viral infection. This binding is of low affinity, and was proved to be directed at the hepatitis B surface antigen, presumably at its disulfide bonds. To avoid false-positive results, this affinity should be considered in the interpretation of immunohistochemical stainings of hepatitis B virus-infected liver tissue with biotinylated reagents.
ISSN: 0022-1554
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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