Title: Potential of amorphous microporous silica for ibuprofen controlled release
Authors: Aerts, C.A. ×
Verraedt, Els
Depla, Anouschka
Froyen, Ludo
Van Humbeeck, Jan
Augustijns, Patrick
Van den Mooter, Guy
Mellaerts, Randy
Martens, Johan #
Issue Date: 2010
Publisher: Elsevier/North Holland
Series Title: International Journal of Pharmaceutics vol:397 pages:84-91
Abstract: Amorphous microporous silica (AMS) xerogel materials were synthesized in an acid-catalyzed sol–gel
process. The porosity of AMS was adapted by varying sol–gel synthesis parameters including the molar
hydrolysis ratio (r-value), HCl:Si molar ratio, the type of silicon alkoxide source and the solvent. AMS
particles of millimeter size were loaded with ibuprofen, by heat treatment and melt impregnation. In vitro
release experiments were performed in simulated gastric and intestinal fluid. The release kinetics were
critically depending on the AMS particle size distribution and the micropore diameter. The release was
interpreted as configurational diffusion in the AMS micropores. The stability of unloaded and ibuprofen
loaded AMS material upon storage was investigated using nitrogen physisorption, DSC analysis and in
vitro release experiments. Ibuprofen loaded AMS formulations show remarkable stability, which can be
attributed to the presence of ibuprofen molecules in the channels, functioning as scaffolds to support the
pore structure.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Laboratory of Molecular Bacteriology (Rega Institute)
Centre for Surface Chemistry and Catalysis
Physical Metallurgy and Materials Engineering Section (-)
× corresponding author
# (joint) last author

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