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Title: Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats
Authors: Delhanty, Patric J D ×
Mesotten, Dieter
McDougall, Fiona
Baxter, Robert C #
Issue Date: Jun-2002
Series Title: Endocrinology vol:143 issue:6 pages:2445-8
Abstract: Growth hormone is an important regulator of metabolism; both acromegaly and GH therapy in GH-deficiency are associated with a tendency towards insulin-resistance and loss of adiposity. A possible mediator of these effects is the recently identified white adipose tissue (WAT)-derived factor resistin that has been shown to impair glucose tolerance and inhibit adipocyte differentiation. We found that WAT resistin gene expression was significantly suppressed in GH-deficient (SDR) rats compared with their Sprague-Dawley background strain. However, within 4 h of treatment of SDRs with a bolus of rhGH (1.5 mg/kg) there was a significant 150-170% increase in WAT resistin mRNA. Moreover, 24 h continuous infusion of recombinant human GH (1 mg/kg/day) caused marked increases in epididymal and subcutaneous WAT resistin of 720% and 950%, respectively, compared to controls. By 48 h of infusion these values had fallen to 510% and 330%. Infusion of porcine GH (1 mg/kg/day) had a similar inductive effect on WAT resistin mRNA. Our data demonstrate an unexpected marked, rapid and sustained up-regulation of resistin by GH. This may indicate a role for resistin in GH-dependent metabolic and differentiative effects in WAT.
URI: 
ISSN: 0013-7227
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Intensive Care Medicine
× corresponding author
# (joint) last author

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