Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing
Akl, Haidar × Badran, Bassam Dobirta, Gratiela Manfouo-Foutsop, Germain Moschitta, Maria Merimi, Makram Burny, Arsene Martiat, Philippe Willard-Gallo, Karen E #
Biomed central ltd
Virology journal vol:4 pages:-
Background: HTLV-1 infected CD4(+) T- cells lines usually progress towards a CD3- or CD3(low) phenotype. In this paper, we studied expression, kinetics, chromatin remodeling of the CD3 gene at different time- points post HTLV-1 infection.