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Title: TGF-beta modulates beta-Catenin stability and signaling in mesenchymal proliferations
Authors: Amini Nik, Saeid ×
Ebrahim, Rasoul Pour
Van Dam, Kim
Cassiman, Jean-Jacques
Tejpar, Sabine #
Issue Date: Aug-2007
Series Title: Experimental cell research vol:313 issue:13 pages:2887-95
Abstract: Here for the first time we showed, despite the oncogenic mutations in beta-Catenin, that TGF-beta is a modulator of beta-Catenin levels in tumoral fibroblasts as well as non-tumoral fibroblasts. The results show that the TGF-beta pathway is active in desmoids cells and in in situ tumors. A dose dependent increase in beta-Catenin protein levels was observed after TGF-beta treatment in combination with an increased repression of GSK-3beta both in normal and tumoral fibroblasts. TGF-beta stimulation also led to an altered -- up to 5 fold -- transcriptional activity of beta-Catenin responsive promoters, such as IGFBP6 as well as increase of TOPflash activity. TGF-beta stimulation increased cell proliferation and BrdU incorporation 2.5 times. Taken together, we propose that TGF-beta is a modulator of beta-Catenin levels in tumoral fibroblasts and non-tumoral fibroblasts, despite the oncogenic mutations already present in this gene in tumoral fibroblasts of desmoid tumors. This modulation of beta-Catenin levels by TGF-beta may be involved in determining the tumoral phenotype of the cells.
URI: 
ISSN: 0014-4827
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Department of Human Genetics - miscellaneous
Forensic Biomedical Sciences
Molecular Digestive Oncology (+)
× corresponding author
# (joint) last author

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