Title: Crystallization and preliminary X-ray study of the d-altritol oligonucleotide GTGTACAC
Authors: Ovaere, Margriet
Van Aerschot, Arthur
Abramov, Mikhail
Herdewijn, Piet
Van Meervelt, Luc # ×
Issue Date: Apr-2010
Publisher: Wiley-blackwell publishing, inc
Series Title: Acta Crystallographica F, Structural Biology and Crystallization Communications Online vol:66 pages:460-462
Abstract: In altritol nucleic acids (ANAs), the natural five-membered ribose ring of RNA is replaced by the six-membered d-altritol ring. ANAs are good candidates to act as siRNAs in the RNA-interference pathway. Crystals of the fully modified altritol self-complementary octamer GTGTACAC were grown by the hanging-drop vapour-diffusion technique at 289 K. Diffraction data were recorded on SLS beamline X06DA and processed to 3.0 A resolution. The crystals belonged to the hexagonal space group P6(1)22 or P6(5)22, with unit-cell parameters a = 25.05, c = 117.58 A.
ISSN: 1744-3091
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Chemistry - miscellaneous
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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