Title: Factors influencing depression endpoints research (FINDER): study design and population characteristics
Authors: Garcia-Cebrian, Ana ×
Bauer, Michael
Montejo, Angel L
Dantchev, Nicolas
Demyttenaere, Koen
Gandhi, Paul
Grassi, Luigi
Monz, Brigitta U
Perahia, David G S
Quail, Deborah
Tylee, Andre #
Issue Date: Jan-2008
Series Title: European psychiatry : the journal of the Association of European Psychiatrists vol:23 issue:1 pages:57-65
Abstract: Factors influencing outcomes of depression in clinical practice, especially health-related quality of life (HRQoL), are poorly understood. The Factors Influencing Depression Endpoints Research (FINDER) study is a European prospective, observational study designed to estimate the HRQoL of adults with a clinically diagnosed depressive episode at baseline, and 3 and 6 months after commencing antidepressant medication. We report here the study design and baseline patient characteristics. HRQoL was assessed by the 36-item Short-Form Health Survey (SF-36) and European Quality of Life-5 Dimensions (EQ-5D). Patient ratings on Hospital Anxiety and Depression Scale (HADS) and pain Visual Analogue Scale (VAS) were also obtained. Results (n=3468) showed that SF-36 mental component summary (mean 22.2) was more than two SDs below general population norms (mean 50.0) and one SD below clinical depression norms (mean 34.8); the physical component summary (mean 46.1) was similar to general population (mean 50.0) and clinical depression norms (mean 45.0). Mean EQ-5D scores were also lower than general population norms. Mean HADS-Depression and -Anxiety subscores were 12.3 and 13.0, respectively. Fifty-six percent of patients reported an overall pain VAS score of at least 30mm and 70% of these patients had no physical explanation for their pain. Further investigation into factors associated with HRQoL in depression after treatment initiation is warranted.
ISSN: 0924-9338
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Psychiatry (-)
× corresponding author
# (joint) last author

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