Cardiovascular and biochemical risk factors for incident dementia in the Hypertension in the Very Elderly Trial
Peters, Ruth × Poulter, Ruth Beckett, Nigel Forette, Francoise Fagard, Robert Potter, John Swift, Cameron Anderson, Craig Fletcher, Astrid Bulpitt, Christopher J #
Lippincott williams & wilkins
Journal of hypertension vol:27 issue:10 pages:2055-2062
Objectives Several cardiovascular and biochemical factors including hypertension have been associated with cognitive decline and dementia, although both epidemiological and intervention evidence is mixed with the majority of studies examining those in midlife or younger elderly and the recent Hypertension in the Very Elderly Trial showing no significant association between blood pressure lowering and incident dementia. It has also been suggested that risk factors may differ in the very elderly. The aim of these analyses was to examine the impact of baseline cardiovascular and biochemical factors upon incident dementia and cognitive decline in a very elderly hypertensive group.