ITEM METADATA RECORD
Title: Targeting voltage sensors in sodium channels with spider toxins
Authors: Bosmans, Frank ×
Swartz, Kenton J #
Issue Date: Apr-2010
Publisher: Elsevier science london
Series Title: Trends in pharmacological sciences vol:31 issue:4 pages:175-182
Abstract: Voltage-activated sodium (Nav) channels are essential in generating and propagating nerve impulses, placing them amongst the most widely targeted ion channels by toxins from venomous organisms. An increasing number of spider toxins have been shown to interfere with the voltage-driven activation process of mammalian Nav channels, possibly by interacting with one or more of their voltage sensors. This review focuses on our existing knowledge of the mechanism by which spider toxins affect Nav channel gating and the possible applications of these toxins in the drug discovery process.
URI: 
ISSN: 0165-6147
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science