Title: Twin anemia polycythemia sequence from a prenatal perspective
Authors: Gucciardo, Léonardo ×
Lewi, Liesbeth
Vaast, Pascal
Debska, Marzena
De Catte, Luc
Van Mieghem, Tim
Done, Elisa
Devlieger, Roland
Deprest, Jan #
Issue Date: May-2010
Publisher: John Wiley & Sons
Series Title: Prenatal Diagnosis vol:30 issue:5 pages:438-42
Abstract: OBJECTIVES: To describe the prevalence, management and outcome of spontaneous twin anemia polycythemia sequence (TAPS) diagnosed in the prenatal period. METHOD: Retrospective analysis of 142 consecutive monochorionic twin pregnancies not diagnosed with twin to twin transfusion syndrome. TAPS cases were identified based on the presence of discordant middle cerebral artery peak systolic velocity (MCA-PSV) measurements and signs suggestive of a chronic intertwin transfusion imbalance: either an elevated reticulocyte count in the anemic twin or the presence of few small unidirectional anastomoses during fetoscopy or at postnatal placental examination. RESULTS: Three cases were identified, giving an estimated prevalence of 2%. Prenatal interventions were tailored to the characteristics of each case and consisted of intrauterine transfusion and interruption of the shared circulation by cord coagulation or laser separation. CONCLUSION: In monochorionic twin pregnancies, TAPS is an uncommon prenatal finding. Nonetheless, its incidence seems high enough to recommend screening for this disease by MCA-PSV measurements.
ISSN: 0197-3851
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pathophysiology of Pregnancy Section (-)
Section Woman - Miscellaneous (-)
Foetal Medicine Section (-)
Organ Systems (+)
× corresponding author
# (joint) last author

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