Title: Systematic reviews of diagnostic research. Considerations about assessment and incorporation of methodological quality
Authors: de Vet, H C ×
van der Weijden, T
Muris, J W
Heyrman, Jan
Buntinx, Frank
Knottnerus, J A #
Issue Date: Jan-2001
Series Title: European journal of epidemiology vol:17 issue:4 pages:301-6
Abstract: The aim of this paper is to provide a theoretical background for performing and reading systematic reviews of diagnostic studies. We first discuss items for assessment of methodological quality in diagnostic studies and then present methods on how to incorporate these quality measures in systematic reviews. The items of internal validity determine whether the presented results of the individual studies are unbiased and can be trusted. Items of external validity determine to what extent the results are applicable outside the population in which the study was performed. The issues concern the adequacy of the study population, the performance and interpretation of the diagnostic tests and the presentation of the results. Several methods exist for incorporation of issues of methodological quality into systematic reviews, such as subgroup analyses, meta-regression analysis, and methodological scores. Publications of diagnostic studies should provide sufficient information to enable assessment of the methodological quality. Furthermore, publication of results of subgroup analyses should be promoted. Methodological criteria lists might help to improve the quality of systematic reviews of diagnostic research. With the items of methodological quality in mind the general practitioner might be better equipped to critically read and interpret diagnostic reviews.
ISSN: 0393-2990
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
× corresponding author
# (joint) last author

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