Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: Results of a randomized trial in patients with advanced colorectal cancer
Kohne, CH × Schöffski, Patrick Wilke, H Kaufer, C Andreesen, R Ohl, U Klaasen, U Westerhausen, M Hiddemann, W Schott, G Harstick, A Bade, J Horster, A Schubert, U Hecker, H Dorken, B Schmoll, HJ #
Grune & Stratton
Journal of Clinical Oncology vol:16 issue:2 pages:418-426
Purpose: To determine whether high-dose infusional fluorouracil (FU) is effectively modulated by leucovorin (LV), interferon (IFN) alpha-2b, or both when given to patients with metastatic colorectal cancer.