Title: Interferon-alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal-cancer - first results of a randomized multicenter study by the association-of-medical-oncology-of-the-german-cancer-society (aio)
Authors: Kohne, Ch ×
Wilke, H
Hecker, H
Schöffski, Patrick
Kaufer, C
Rauschecker, H
Andreesen, R
Ohl, U
Lange, Hj
Klaassen, U
Westerhausen, M
Hiddemann, W
Hennemann, B
Schott, G
Bade, J
Strohmeyer, G
Harstrick, A
Schubert, U
Bokemeyer, C
Schmoll, Hj #
Issue Date: May-1995
Publisher: Kluwer academic publ
Series Title: Annals of oncology vol:6 issue:5 pages:461-466
Abstract: Background: High-dose 5-FU given weekly as a 24-h infusion in combination with folinic acid (FA) has been associated with low toxicity and a high response rate. Interferon-alpha (IFN) either alone or in combination with FA has also improved treatment results by modulating 5-FU activity. We therefore initiated a randomized multicenter trial comparing the ability of FA or IFN to modulate infusional 5-FU. The statistical design using a sequential analysis allows us to report on the comparison of 5-FU/FA vs. 5-FU/FA/IFN while randomization of patients into 5-FU/FA vs. 5 FU/IFN continues.
ISSN: 0923-7534
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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