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Title: Epirubicin dacarbazine rapidly alternated with ifosfamide in the treatment of metastatic soft-tissue sarcomas
Authors: Bokemeyer, C ×
Harstrick, A
Schmoll, Hj
Kohnewompner, Ch
Schöffski, Patrick
Poliwoda, H #
Issue Date: Jun-1992
Publisher: Kluwer Academic Publishers
Series Title: Annals of Oncology vol:3 issue:6 pages:487-488
Abstract: Twenty-eight patients with non-pretreated metastatic soft tissue sarcomas were entered on a treatment protocol of rapidly alternating epirubicin/dacarbazine and ifosfamide: Epirubicin 100 mg/m2 d1, dacarbazine 500 mg/m2 d1 + d2, ifosfamide 6000 mg/m2 24-h infusion d15; repeated d29. Eight patients (30%) achieved partial responses, with a median duration of 8.5 months. The median time to progression was 5.5 months. Myelosuppression was the main toxicity. Only 74% of the planned dose intensity could be administered. This rapidly alternating treatment protocol is not superior to anthracycline single agent therapy.
ISSN: 0923-7534
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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