Title: Activity of docetaxel (taxotere) in small-cell lung-cancer
Authors: Smyth, Jf ×
Smith, Ie
Sessa, C
Schöffski, Patrick
Wanders, J
Franklin, H
Kaye, Sb #
Issue Date: 1994
Publisher: Pergamon
Series Title: European Journal of Cancer vol:30A issue:8 pages:1058-1060
Abstract: Docetaxel (Taxotere) is a new cytotoxic compound with a broad spectrum of activity in preclinical studies. This paper reports a phase II trial in patients with previously-treated small cell carcinoma of the lung. 34 patients received 100 mg/m(2) of docetaxel in an intravenous infusion given over 1 h every 21 days. Seven partial responses were reported (25% of 28 evaluable patients). Duration of response was 3.5-12.6 months. Toxicities were predominantly neutropenia, alopecia and asthenia. Docetaxel is a new compound with activity in previously-treated patients with small cell lung cancer, and is suitable for evaluation in combination with other cytotoxic drugs active in this disease.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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