Title: Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors
Authors: Beutel, G ×
Glen, H
Schöffski, Patrick
Chick, J
Gill, S
Cassidy, J
Twelves, C #
Issue Date: Aug-2005
Publisher: Association for Cancer Research
Series Title: Clinical Cancer Research vol:11 issue:15 pages:5487-5495
Abstract: Purpose: OSI-7904L is a liposomal formulation of a potent noncompetitive thymidylate synthase inhibitor (TSI) that does not require polyglulamation for activity. This phase I study was done to establish the safety, tolerability, maximum tolerated dose, recommended dose, and pharmacokinetics of OSI-7904L in patients with advanced solid tumors refractory to standard therapy.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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