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Title: An overview of group sequential methods in longitudinal clinical trials
Authors: Spiessens, Bart ×
Lesaffre, Emmanuel
Verbeke, Geert
Kim, K
DeMets, D L #
Issue Date: Oct-2000
Series Title: Statistical methods in medical research vol:9 issue:5 pages:497-515
Abstract: During the last decade, several papers have been published on group sequential methods in general and on sequential longitudinal clinical trials in particular. This paper gives an overview of the proposed methods, emphasizing longitudinal clinical trials. Furthermore, it tries to answer some practical questions that may arise during the conduct of interim analyses in longitudinal trials. Simulations have been carried out to obtain insight in these practical considerations.
URI: 
ISSN: 0962-2802
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
× corresponding author
# (joint) last author

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