Title: Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation
Authors: Kumar, Davinder ×
Judge, Vikramjeet
Narang, Rakesh
Sangwan, Sonia
De Clercq, Erik
Balzarini, Jan
Narasimhan, Balasubramanian #
Issue Date: Jul-2010
Series Title: European Journal of Medicinal Chemistry vol:45 issue:7 pages:2806-2816
Abstract: A series of benzylidene hydrazides (1-20) was synthesized and tested, in vitro, for antibacterial, antifungal and antiviral activities. The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. The antiviral evaluation depicted that compounds 9 and 19 were active against Vesicular stomatitis virus (VSV) in HeLa cell cultures. QSAR investigations indicated that the multi-target QSAR model was effective in describing the antimicrobial (antibacterial and antifungal) activity over the one-target QSAR models. Further the mt-QSAR model indicated that the topological parameters, second order molecular connectivity index ((2)chi) and third order Kier's alpha shape index (kappaalpha(3)) are effective in describing the antimicrobial activity of synthesized hydrazides.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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