Title: Synthetic Exploration of Oxacalix[2]arene[2]quinazolines
Authors: Van Rossom, Wim
Kishore, Lingam
Robeyns, Koen
Van Meervelt, Luc
Dehaen, Wim ×
Maes, Wouter #
Issue Date: Jul-2010
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:21 pages:4122-4129
Abstract: Oxacalix[2]arene[2]quinazoline macrocycles were prepared in good yields, as mixtures of syn- and anti-isomers, through nucleophilic aromatic substitution cyclocondensation reactions of 2,4-dichloro-quinazolines and m-dihydroxybenzenes. The macrocyclization conditions were optimized and the isomeric ratio was investigated by means of one-step and fragment-coupling approaches. The oxacalixarene substitution pattern could easily be varied by altering the dichloroquinazolinyl biselectrophilic and dihydroxyaryl bisnucleophilic building blocks. The solid-state (1,3-alternate) conformational behaviour and the oxacalix[4]arene cavity size were explored by X-ray diffraction studies.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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