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Title: Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
Authors: Kleppe, Maria
Lahortiga, Idoya
El Chaar, Tiama
De Keersmaecker, Kim
Mentens, Nicole
Graux, Carlos
Van Roosbroeck, Katrien
Ferrando, Adolfo A
Langerak, Anton W
Meijerink, Jules P P
Sigaux, François
Haferlach, Torsten
Wlodarska, Iwona
Vandenberghe, Peter
Soulier, Jean
Cools, Jan # ×
Issue Date: May-2010
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:42 issue:6 pages:530-535
Abstract: PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. In agreement with its role in the regulation of the immune system, PTPN2 was identified as a susceptibility locus for autoimmune diseases. In this work, we describe the identification of focal deletions of PTPN2 in human T-cell acute lymphoblastic leukemia (T-ALL). Deletion of PTPN2 was specifically found in T-ALLs with aberrant expression of the TLX1 transcription factor oncogene, including four cases also expressing the NUP214-ABL1 tyrosine kinase. Knockdown of PTPN2 increased the proliferation and cytokine sensitivity of T-ALL cells. In addition, PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity. Our study provides genetic and functional evidence for a tumor suppressor role of PTPN2 and suggests that expression of PTPN2 may modulate response to treatment.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory of Molecular Biology of Leukemia
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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