IgG Antibodies against Deamidated Gliadin Peptides for Diagnosis of Celiac Disease in Patients with IgA Deficiency
Villalta, Danilo × Tonutti, Elio Prause, Christian Koletzko, Sibylle Uhlig, H. Holm Vermeersch, Pieter Bossuyt, Xavier Stern, Martin Laass, Martin W Ellis, Julia H Ciclitira, Paul J Richter, Thomas Daehnrich, Cornelia Schlumberger, Wolfgang Mothes, Thomas #
Amer assoc clinical chemistry
Clinical Chemistry vol:56 issue:3 pages:464-8
BACKGROUND: Assays for IgG antibodies against deamidated gliadin (IgG-anti-dGli) are comparable in performance with tests detecting IgA antibodies against tissue transglutaminase (IgA-anti-tTG) in diagnosing celiac disease (CD). IgA-anti-tTG are absent in IgA deficiency, a condition often associated with CD. In IgA deficiency, IgG-anti-tTG, which have a lower overall diagnostic accuracy, are routinely measured. We examined whether IgG-anti-dGli would be useful for diagnosing CD in patients with IgA deficiency.