Title: Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity
Authors: Dixit, Evelyn
Boulant, Steeve
Zhang, Yijing
Lee, Amy S Y
Odendall, Charlotte
Shum, Bennett
Hacohen, Nir
Chen, Zhijian J
Whelan, Sean P
Fransen, Marc
Nibert, Max L
Superti-Furga, Giulio
Kagan, Jonathan C # ×
Issue Date: 14-May-2010
Publisher: MIT Press
Series Title: Cell vol:141 issue:4 pages:668-681
Abstract: Peroxisomes have long been established to play a central role in regulating various metabolic activities in mammalian cells. These organelles act in concert with mitochondria to control the metabolism of lipids and reactive oxygen species. However, while mitochondria have emerged as an important site of antiviral signal transduction, a role for peroxisomes in immune defense is unknown. Here, we report that the RIG-I-like receptor (RLR) adaptor protein MAVS is located on peroxisomes and mitochondria. We find that peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. The interferon regulatory factor IRF1 plays a crucial role in regulating MAVS-dependent signaling from peroxisomes. These results establish that peroxisomes are an important site of antiviral signal transduction.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Lipid Biochemistry and Protein Interactions
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science