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Title: Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study (EMAS)
Authors: Lee, David ×
Ulubaev, Aslan
Tajar, Abdelouahid
Pye, Stephen
Pendleton, Neil
Purandare, Nitin
O'Neill, Terence
O'Connor, Daryl
Labrie, Fernand
Platt, Hazel
Payne, Debbie
Bartfai, Gyorgy
Boonen, Steven
Casanueva, Felipe
Finn, Joseph
Forti, Gianni
Giwercman, Aleksander
Han, Thang
Huhtaniemi, Ilpo
Kula, Krzysztof
Lean, Michael
Punab, Margus
Silman, Alan
Vanderschueren, Dirk
Wu, Fredrick #
Issue Date: Mar-2010
Publisher: BioScientifica Ltd.
Series Title: European Journal of Endocrinology vol:162 issue:6 pages:1155-1164
Abstract: Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3,369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical-Recognition-Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone (T), oestradiol (E2) and 5alpha-dihydrotestosterone (DHT) were measured by gas chromatography-mass spectrometry (GC-MS); dehydroepiandrosterone-sulphate (DHEAS), luteinising hormone (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free T/E2 were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping. Results: Total and free T were associated with higher, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (beta=-0.011, P=0.02), although this was driven by subjects with DHEAS levels >10micromol/L. Locally-weighted plots revealed no threshold effects between hormones and fluid cognition. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (beta=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones. Conclusion: Our results suggest endogenous hormones are not associated with a vision-based measure of fluid cognition among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests.
URI: 
ISSN: 0804-4643
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

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