Title: Tracheal allotransplantation after withdrawal of immunosuppressive therapy
Authors: Delaere, Pierre ×
Vranckx, Jan
Verleden, Geert
De Leyn, Paul
Van Raemdonck, Dirk
Annys, Erwin
Vanacker, Bernard
Coosemans, Willy
Dooms, Christophe
Ectors, Nadine
Ferdinande, Patrick
Hauben, Esther
Hermans, Bob
Jorissen, Mark
Nafteux, Philippe
Lerut, Toni
Roskams, Tania
Segers, Katarina
Vanclooster, Christophe
Vander Borght, S
Vander Poorten, Vincent
Van Gelder, F
Van Hees, D
Waer, Mark #
Issue Date: Jan-2010
Publisher: Massachusetts medical soc
Series Title: New England Journal of Medicine vol:362 issue:2 pages:138-145
Abstract: Reconstruction of long-segment tracheal defects requires a vascularized allograft. We report successful tracheal allotransplantation after indirect revascularization of the graft in a heterotopic position. Immunosuppressive therapy was administered before the operation, and the tracheal allograft was wrapped in the recipient's forearm fascia. Once revascularization was achieved, the mucosal lining was replaced progressively with buccal mucosa from the recipient. At 4 months, the tracheal chimera was fully lined with mucosa, which consisted of respiratory epithelium from the donor and buccal mucosa from the recipient. After withdrawal of immunosuppressive therapy, the tracheal allograft was moved to its correct anatomical position with an intact blood supply. No treatment-limiting adverse effects occurred.
ISSN: 0028-4793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Transplantation
Anesthesiology and Algology
Pregnancy, Foetus and Newborn (-)
Thoracic Surgery
Translational Cell & Tissue Research
Laboratory of Intensive Care Medicine
Research Group Experimental Oto-rhino-laryngology
Department of Development and Regeneration - miscellaneous (+)
Head and Neck Oncology (+)
× corresponding author
# (joint) last author

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