Title: Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: Implications for metabolism research
Authors: Martens, Katrin
Bottelbergs, Astrid
Baes, Myriam # ×
Issue Date: Mar-2010
Publisher: Elsevier science bv
Series Title: Febs letters vol:584 issue:5 pages:1054-1058
Abstract: aP2-Cre mice have amply been used to generate conditional adipose selective inactivation of important signaling molecules. We show that the efficiency of Cre mediated recombination in adipocytes and adipose selectivity is not always guaranteed. In particular, Cre activity was found in ganglia of the peripheral nervous system (PNS), in adrenal medulla and in neurons throughout the central nervous system (CNS). Because these tissues have an important impact on adipose tissue, care should be taken when using aP2-Cre mice to define the role of the targeted genes in adipose tissue function. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell Metabolism
× corresponding author
# (joint) last author

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