Title: Adipose tissue expandability and the early origins of PCOS
Authors: de Zegher, Francis ×
Lopez-Bermejo, Abel
Ibanez, Lourdes #
Issue Date: Nov-2009
Publisher: Elsevier Science Pub. Co.
Series Title: Trends in Endocrinology and Metabolism vol:20 issue:9 pages:418-423
Abstract: The most prevalent phenotypes of polycystic ovary syndrome (PCOS) are characterized by insulin resistance and androgen excess. The adipose tissue (AT) expandability hypothesis explains the development of insulin resistance in obesity and in cases of AT deficit. In line with this hypothesis, we propose that hyperinsulinemic androgen excess in PCOS is often underpinned by exhaustion of the capacity to expand subcutaneous AT in a metabolically safe way. Such exhaustion might occur when a positive energy imbalance meets a normal fat-storage capacity and/or when a normal energy balance faces a low fat storage capacity. This concept thus explains how PCOS phenotypes might result from obesity, prenatal growth restraint or a genetic lipodystrophy, or, experimentally, from prenatal androgen excess.
ISSN: 1043-2760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
× corresponding author
# (joint) last author

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