Carboxylation of Osteocalcin Affects Its Association With Metabolic Parameters in Healthy Children
Prats-Puig, Anna × Mas-Parareda, Marta Riera-Perez, Elena Gonzalez-Forcadell, Dolors Mier, Concepcio Mallol-Guisset, Montserrat Diaz, Marta Bassols, Judit de Zegher, Francis Ibanez, Lourdes Lopez-Bermejo, Abel #
Amer diabetes assoc
Diabetes care vol:33 issue:3 pages:661-663
OBJECTIVE - Osteocalcin (OC), a bone-derived protein, was recently shown to regulate metabolic pathways in mice. Undercarboxylated OC (ucOC), but not carboxylated OC (cOC), increases adiponectin and insulin secretion. It is unclear if carboxylation of OC affects its association with metabolic parameters in humans.