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Title: Voltage-gated sodium channels are targets for toxins from the venom of the spider Heriaeus melloteei
Authors: Nikolsky, Anton ×
Billen, Bert
Vassilevski, Alexander
Filkin, S. Yu
Tytgat, Jan
Grishin, Eugene #
Issue Date: Jul-2009
Publisher: Nauka
Series Title: Biologicheskie Membrany vol:26 issue:4 pages:249-257
Abstract: Three novel peptides were isolated from the venom of the spider Heriaeus melloteei (Thomisidae) and characterized. The peptides named Hm-1, 2 and 3 blocked voltage-gated sodium channels at concentrations in the order of 100 nM. Activity of the purified peptides was investigated in sodium channel isoforms of mammals and insects. Hm-1 and 2 appeared to act as pore blockers, whereas Hm-3 modulated the channel activation process. The toxins described exhibit minor similarity with other known peptides and may therefore constitute new groups of sodium channel ligands.
ISSN: 0233-4755
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Structural Neurobiology
Toxicology and Pharmacology
× corresponding author
# (joint) last author

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