Genetic contribution of FUS to frontotemporal lobar degeneration
Van Langenhove, T × van der Zee, J Sleegers, K Engelborghs, S Vandenberghe, Rik Gijselinck, I Van den Broeck, M Mattheijssens, M Peeters, K De Deyn, P. P Cruts, M Van Broeckhoven, C #
Lippincott williams & wilkins
Neurology vol:74 issue:5 pages:366-371
Background: Recently, the FUS gene was identified as a new causal gene for amyotrophic lateral sclerosis (ALS) in similar to 4% of patients with familial ALS. Since ALS and frontotemporal lobar degeneration (FTLD) are part of a clinical, pathologic, and genetic disease spectrum, we investigated a potential role of FUS in FTLD.