Relation of regional cross-fiber shortening to wall thickening in the intact heart - 3-dimensional strain analysis by nmr tagging
Rademakers, Frank × Rogers, WJ Guier, WH Hutchins, GM Siu, CO Weisfeldt, ML Weiss, JL Shapiro, EP #
Amer heart assoc
Circulation vol:89 issue:3 pages:1174-1182
Background The mechanism by which small amounts of myofiber shortening lead to extensive wall thickening is unknown. When isolated fibers shorten, they thicken in the two orthogonal directions. In situ fibers, however, vary in their orientation through the wall, and each is tethered to near or distant neighbors, which allows shortening to occur both in the direction of the fibers and also perpendicular to them. This ''cross-fiber'' shortening may enable the wall to shorten in two directions and thereby thicken extensively in the third.