Title: Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: a case study with itraconazole and eudragit E100
Authors: Janssens, Sandrien
De Zeure, Ann
Paudel, Amrit
Van Humbeeck, Jan
Rombaut, Patrick
Van den Mooter, Guy # ×
Issue Date: Apr-2010
Publisher: Thieme
Series Title: Pharmaceutical Research vol:27 pages:775-785
Abstract: Purpose
The present study aims to determine the drug / polymer miscibility level as a function of the preparation method for an amorphous solid dispersion model system containing itraconazole and eudragit E100. This value was compared to the theoretical crystalline drug solubility in the amorphous polymer and the miscibility of the amorphous drug in the amorphous polymer.

The amorphous solid dispersions were prepared via spray drying and film casting in order to evaluate the influence of the solvent drying rate. The experimental miscibility level was estimated using XRPD, MDSC, FT-IR, HPLC and TGA. The solubility and miscibility were estimated using the Flory-Huggins mixing theory and experimental drug in monomer solubility data.

The experimental miscibility level was found to be 27.5% w/w for spray-dried and 15% for film-casted solid dispersions. FT-IR measurements confirmed the absence of saturable interactions like hydrogen bonds, and analysis of the mixed glass transition temperatures suggested low adhesion forces in the amorphous mixture. The solubility analysis rendered a positive FH interaction parameter, a crystalline solubility of approximately 0.012% w/w and an amorphous drug-polymer miscibility of approximately 7.07% w/w. Conclusion. The solid dispersions are significantly supersaturated with respect to both crystalline solubility and amorphous miscibility demonstrating the influence of manufacturing methodology.
ISSN: 0724-8741
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Physical Metallurgy and Materials Engineering Section (-)
× corresponding author
# (joint) last author

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