Title: Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study
Authors: Van Oudenhove, Lukas ×
Vandenberghe, Joris
Dupont, Patrick
Geeraerts, Brecht
Vos, Rita
Dirix, Stijn
Bormans, Guy
Vanderghinste, Dominique
Van Laere, Koen
Demyttenaere, Koen
Fischler, Benjamin
Tack, Jan #
Issue Date: Apr-2010
Publisher: Nature Publishing Group
Series Title: American Journal of Gastroenterology vol:105 issue:4 pages:913-924
Abstract: OBJECTIVES: During gastric distension in hypersensitive functional dyspepsia (FD), activation was found in somatosensory cortex (SI/SII) and ventrolateral prefrontal cortex (vlPFC) but, contrary to controls, not in pregenual anterior cingulate (pACC). The aims of this article were to study (i) cortical activations and deactivations during distension and sham compared with baseline in FD, regardless of sensitivity status; (ii) differences in brain activity between health and FD during "no distension" conditions; and (iii) the relationship between anxiety and brain activity in FD. METHODS: Brain H(2)(15)O-PET was performed in 25 FD patients (13 hypersensitive) during three conditions: baseline, distension at discomfort threshold, and sham. Brain activity was compared against healthy controls using SPM2. RESULTS: Discomfort threshold was lower; sensation scores in all conditions were higher in patients than controls. (i) Activations were similar to controls, except for a lack of pACC activation during distension in FD. Patients showed no dorsal pons and amygdala deactivation during distension and sham, respectively. (ii) Comparing baseline or sham activity showed the following differences: higher activity in SII/SI, insula, midcingulate (MCC), dorsolateral and ventrolateral PFC in controls; and higher activity in occipital cortex in FD. Differences in left lateral PFC were specific to sham. (iii) Anxiety correlated negatively with pACC and MCC and positively with dorsal pons activity. CONCLUSIONS: FD patients failed to activate pACC, to deactivate dorsal pons during distension, and to deactivate amygdala during sham; this may represent arousal-anxiety-driven failure of pain modulation. During baseline and sham, differences between patients and controls were found in sensory as well as affective-cognitive areas.
ISSN: 0002-9270
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Psychiatry
Research Group Experimental Neurology
Translational Research in GastroIntestinal Disorders
Laboratory for Cognitive Neurology
Radiopharmaceutical Research
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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