Title: Diagnostic pitfalls in digestive neuroendocrine tumours
Authors: Borbath, I ×
Jamar, F
Delaunoit, T
Demetter, P
Demolin, G
Hendlisz, A
Pattyn, P
Peeters, M
Roeyen, G
Van Cutsem, Eric
Van Hootegem, Philippe
Van Laethem, J L
Verslype, Chris
Pauwels, S #
Issue Date: Jan-2009
Publisher: Univ catholique louvain-ucl
Series Title: Acta Gastro-Enterologica Belgica vol:72 issue:1 pages:29-33
Abstract: Gastro-entero-pancreatic neuroendocrine tumours (GEP NET) represent a rare and highly heterogeneous entity that often is revealed by vague and non-specific symptoms, leading to a delayed diagnosis. Here we will review some of the most regularly observed false positive and false negative cases and provide clues to recognize and manage them properly. Particularly, the value of chromogranin-A as a serum tumour marker and Somatostatin receptor scintigraphy as an imaging test, are reviewed. Indeed, chromogranin-A and other hormones, such as gastrin, as well as urinary 5-hydroxy-indolic acetic acid (5-HIAA) are often tested to diagnose NET without appraising the clinical situation, leading to extensive work-up on false bases. On the other hand, some tests are performed in situations where they do not add additional information (e.g. 5-HIAA in pancreatic or rectal NET) because invariably negative. Somatostatin receptor scintigraphy is an expensive examination, still not reimbursed in Belgium, for which indications must be carefully assessed, knowing its specificity and sensitivity. (Acta gastroenterol. belg., 2009, 72, 29-33).
ISSN: 0001-5644
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
Translational Research in GastroIntestinal Disorders
Clinical Digestive Oncology (+)
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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