Title: Benchmarks for Cystic Fibrosis carrier screening: A European consensus document
Authors: Castellani, Carlo ×
Macek, Milan
Cassiman, Jean-Jacques
Duff, Alistair
Massie, John
Ten Kate, Leo P
Barton, David
Cutting, Garry
Dallapiccola, Bruno
Dequeker, Elisabeth
Girodon, Emmanuelle
Grody, Wayne
Highsmith, Edward W
Kääriäinen, Helenal
Kruip, Stephan
Morris, Michael
Pignatti, Pier Franco
Pypops, Ulrike
Schwarz, Martin
Soller, Maria
Stuhrman, Manfred
Cuppens, Harry #
Issue Date: May-2010
Series Title: Journal of Cystic Fibrosis vol:9 issue:3 pages:165-178
Abstract: This paper presents an overview of the conclusions from an international conference convened to address current issues related to the provision of Cystic Fibrosis carrier screening within Europe. Consensus was not aimed at stating whether such a programme should be implemented. Instead the focus was to provide a framework for countries and agencies who are considering or planning its establishment. The general principles and target population of Cystic Fibrosis carrier screening, advantages and disadvantages, health economics, monitoring and future evaluative and research directions were covered. A range of screening strategies have been assessed and compared: pre-conceptional and prenatal screening; individual and couple screening; sequential and simultaneous sampling or testing. Furthermore, technical issues were examined with respect to the choice of the panel of mutations, its detection rate, sensitivity, management of intermediate 'at-risk' couples, screening approach to different populations and ethnic minorities, and assurance of laboratory quality control. The consensus statement also aims to establish the benchmarks for communicating with health care providers, the general public and potential and actual participants before and after the genetic test.
ISSN: 1569-1993
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Forensic Biomedical Sciences
Biomedical Quality Assurance Research Unit
× corresponding author
# (joint) last author

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