Title: A placebo-controlled randomized crossover trial of the N-methyl-D-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain
Authors: Wiech, Katja ×
Kiefer, Ralph T.
Topfner, Stephanie
Preissl, Hubert
Braun, Christoph
Unertl, Klaus
Flor, Herta
Birbaumer, Niels #
Issue Date: Feb-2004
Publisher: Lippincott williams & wilkins
Series Title: Anesthesia and analgesia vol:98 issue:2 pages:408-413
Abstract: In the present study we investigated the effect of the N-methyl-D-aspartic acid (NMDA) receptor antagonist memantine (30 mg/d) on the intensity of chronic phantom limb pain (PLP) and cortical reorganization. In 8 patients with chronic PLP, memantine was tested in a placebo-controlled double-blinded crossover trial of 4 wk duration per trial. The intensity of PLP was rated hourly by the patients on a visual analog scale during baseline and both treatment periods. At the same time points, the functional organization of the primary somatosensory cortex (SI) was determined by neuromagnetic source imaging. In comparison to baseline and placebo, the NMDA receptor antagonist had no effect on the intensity of chronic PLP. In none of the periods were significant changes in the functional organization of SI observed. Although the conclusions regarding the clinical effect are limited because of the small sample size, the data indicate that in the studied dosage the NMDA receptor antagonist memantine is ineffective in the treatment of chronic PLP and is also ineffective for the reduction of associated neural plasticity in the primary SI.
ISSN: 0003-2999
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Health Psychology
× corresponding author
# (joint) last author

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