Journal of controlled release vol:142 issue:1 pages:47-52
A new system for the controlled release of the antiseptic chlorhexidine is presented. Amorphous microporous silica (AMS) excipient material was synthesized via an acid catalyzed sol-gel method and shaped as powder or coating. Chlorhexidine diacetate was introduced into the pores of the AMS silica via the incipient wetness impregnation method. This silica reservoir maintained a slow release of chlorhexidine over more than 7 days. Chlorhexidine release was controlled by configurational diffusion in the AMS pores having free diameters of less than 1 nm. The release of chlorhexidine was fine tuned by adapting particle size and pore diameter. Controlled release of chlorhexidine from an AMS coating on silicon wafer was demonstrated. (C) 2009 Elsevier B.V. All rights reserved.