Title: Renal Side Effects of Non-Steroidal anti-Inflammatory Drugs in Neonates
Authors: Allegaert, Karel ×
de Hoon, Jan
Debeer, Anne
Gewillig, Marc #
Issue Date: 3-Feb-2010
Publisher: Molecular Diversity Preservation International
Series Title: Pharmaceuticals vol:3 issue:2 pages:393-405
Abstract: Non-steroidal anti-inflammatory drugs like ibuprofen or indomethacin are commonly prescribed drugs to induce pharmacologic closure of a patent ductus arteriosus in preterm neonates. Based on a recently published Cochrane meta-analysis, both drugs are equally effective to induce closure. Drug choice can therefore be based on differences in side effects or pharmaco-economic arguments. The current review quantifies the negative impact of either ibuprofen or indomethacin on renal function, including diuresis, glomerular filtration rate and renal tubular function. Both ibuprofen and indomethacin have a quantifiabel impact on renal function. However, compared to ibuprofen, the negative impact of indomethacin is more pronounced.
ISSN: 1424-8247
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Pharmacology Centre (-)
Section Newborn (-)
Pediatric Cardiology Section (-)
Cardiovascular Developmental Biology
× corresponding author
# (joint) last author

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