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Title: PIK3CA Mutations Are Not a Major Determinant of Resistance to the Epidermal Growth Factor Receptor Inhibitor Cetuximab in Metastatic Colorectal Cancer
Authors: Prenen, Hans ×
De Schutter, Jef
Jacobs, Bart
De Roock, Wendy
Biesmans, Bart
Claes, Bart
Lambrechts, Diether
Van Cutsem, Eric
Tejpar, Sabine #
Issue Date: May-2009
Publisher: Amer assoc cancer research
Series Title: Clinical Cancer Research vol:15 issue:9 pages:3184-3188
Abstract: Purpose: It has been reported that activating KRAS mutations negatively affect response to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in metastatic colorectal cancer. The mutation status of signaling molecules downstream of the EGFR target is thus crucial to predict clinical benefit to EGFR-targeted therapies. Other mechanisms of resistance to EGFR inhibitors could involve activating mutations of the other main EGFR effector pathway, i.e., the PI3K/PTEN/AKT pathway.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Translational Genetics (Vesalius Research Center) (+)
Molecular Digestive Oncology (+)
Clinical Digestive Oncology (+)
Vesalius Research Centre (-)
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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