Title: Site-specific labeling of 'second generation' annexin V with Tc-99m(CO)(3) for improved imaging of apoptosis in vivo
Authors: De Saint-Hubert, Marijke ×
Mottaghy, Felix M
Vunckx, Kathleen
Nuyts, Johan
Fonge, Humphrey
Prinsen, Kristof
Stroobants, Sigrid
Mortelmans, Luc
Deckers, Niko
Hofstra, Leo
Reutelingsperger, Chris P. M
Verbruggen, Alfons
Rattat, Dirk #
Issue Date: Feb-2010
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry vol:18 issue:3 pages:1356-1363
Abstract: In this study 'second generation' AnxV was specifically labeled with Tc-99m in three different ways outside the binding region of the protein to obtain an improved target-to-background activity ratio. The compounds were tested in vitro and in vivo in normal mice and in a model of hepatic apoptosis (anti-Fas mAb). The apoptosis binding was most prominent for the HIS-tagged 'second generation' AnxV labeled with Tc-99m(CO)(3) in comparison to Tc-99m-HYNIC-cys-AnxV and Tc-99m(CO)(3)-DTPA-cys-AnxV. (C) 2009 Elsevier Ltd. All rights reserved.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Radiopharmaceutical Research
× corresponding author
# (joint) last author

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