Title: A pilot trial of microplasmin in patients with long-term venous access catheter thrombosis
Authors: Verhamme, Peter ×
Jérôme, Martine
Goossens, Godelieve
Devis, Joanna
Maleux, Geert
Stas, Marguerite #
Issue Date: 2009
Publisher: Kluwer Academic Publishers
Series Title: Journal of Thrombosis and Thrombolysis vol:28 issue:4 pages:477-481
Article number: 19225865
Abstract: Background Microplasmin, a truncated form of plasmin, degrades fibrin and reacts with the circulating inhibitor α2-antiplasmin. We investigated the safety and efficacy of intra-catheter microplasmin bolus administration for the restoration of catheter function in long-term venous access catheter thrombosis. Methods This open-label, ascending-dose, pilot study enrolled 31 subjects. Two doses of microplasmin were evaluated, (5 mg and 8 mg) administered via a 2 ml intra-catheter bolus injection in 10 and 21 patients respectively. Catheter function was evaluated 30 min after the first bolus administration. In case of incomplete catheter function restoration, a second bolus was administered with reassessment of catheter function 30 min thereafter. Results After the first bolus, complete restoration of catheter withdrawal function was observed in 5 out of 10 (50%) and 14 of out 21 (66%) subjects treated with 5 mg and 8 mg respectively and in 8 out of 10 (80%) and 18 out of 21 (86%) subjects after a second administration of microplasmin. No bleeding complications nor other adverse events were related to microplasmin. Conclusions In this pilot trial, microplasmin restored catheter function in a safe and effective way.
ISSN: 0929-5305
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Centre for Nursing and Midwifery
Surgical Oncology
Molecular and Vascular Biology
× corresponding author
# (joint) last author

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