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Title: Clinical course and prognostic value of disease activity in the first two years in different subtypes of juvenile idiopathic arthritis
Authors: Albers, H M ×
Brinkman, D M C
Kamphuis, S S M
van Suijlekom-Smit, L W A
van Rossum, M A J
Hoppenreijs, E P A H
Girschick, H J
Wouters, Carine
Saurenmann, R K
Houwing-Duistermaat, J J
Huizinga, T W J
Schilham, M W
ten Cate, R #
Issue Date: Feb-2010
Publisher: John Wiley & Sons, Inc.
Series Title: Arthritis Care & Research vol:62 issue:2 pages:204-212
Abstract: OBJECTIVE: Juvenile idiopathic arthritis (JIA) is a heterogeneous disease involving chronic arthritis. The clinical course is characterized by a fluctuating pattern of active and inactive disease. We have described in detail the clinical course in different JIA subtypes during the first 2 years after diagnosis and studied its relationship to disease activity in the following years. METHODS: Detailed clinical data on different parameters describing the disease activity in sequential time periods covering the first 2 years after diagnosis were retrieved from the charts of 311 patients with JIA and compared between subtypes. In a cohort of 146 patients, the relation of these different clinical variables to the course of disease in the following 3 years was evaluated. RESULTS: The percentage of time with active disease in the first 2 years differed significantly between subtypes. In all subtypes, a broad spectrum of activity was observed. The time with active disease in the first 2 years was the most significant factor associated with the duration of active disease in the following years. CONCLUSION: Different percentages of time with active disease have been observed between JIA subtypes in the first 2 years. The cumulative duration of activity varied widely within each subtype. Regarding the prognosis of the individual patient, the clinical course in the first 2 years appears to be predictive of the clinical course in the following years. Patients that have less time with active disease in the first 2 years are not likely to develop an unremitting clinical course later on.
URI: 
ISSN: 2151-464X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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