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Title: Serum (1-3)-beta-D-glucan as a tool for diagnosis of Pneumocystis jirovecii pneumonia in patients with human immunodeficiency virus infection or hematological malignancy
Authors: Desmet, Stefanie ×
Van Wijngaerden, Eric
Maertens, Johan
Verhaegen, Jan
Verbeken, Eric
De Munter, Paul
Meersseman, Wouter
Van Meensel, Britt
Van Eldere, Johan
Lagrou, Katrien #
Issue Date: Dec-2009
Publisher: American Society for Microbiology (ASM)
Series Title: Journal of Clinical Microbiology vol:47 issue:12 pages:3871-3874
Abstract: (1-3)-Beta-D-Glucan (BG) reactivity was tested in serum samples from 28 patients with human immunodeficiency virus infection or a hematological malignancy and Pneumocystis jirovecii pneumonia (PCP) and 28 control patients. The sensitivity and specificity of BG detection with the Fungitell assay for PCP were 100 and 96.4%, respectively, using a cutoff value of 100 pg/ml. Serum BG testing looks promising for the noninvasive diagnosis of PCP. Our data suggest that a higher cutoff value for the diagnosis of PCP than for the diagnosis of invasive aspergillosis or candidiasis could be used safely and will improve the specificity of the test.
URI: 
ISSN: 0095-1137
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Clinical Infectious and Inflammatory Disorders
Hematology Section (-)
Laboratory of Clinical Bacteriology and Mycology
Translational Cell & Tissue Research
Laboratory for Experimental and Clinical Microbiology (-)
× corresponding author
# (joint) last author

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