Title: Nucleic Acids with a Six-Membered 'Carbohydrate' Mimic in the Backbone
Authors: Herdewijn, Piet # ×
Issue Date: 2010
Publisher: Wiley-v c h verlag gmbh
Series Title: Chemistry & biodiversity vol:7 issue:1 pages:1-59
Abstract: Starting from pyranose nucleic acids, several series of modified nucleic acids with a six-membered carbohydrate moiety (mimic) have been synthesized and analyzed over a period of 20 years, and this work is summarized here. The process starts with structural and conformational considerations, followed by synthetic efforts and a structural analysis, and ends up with a biological confirmation of the concept, demonstrating that these modified nucleic acids represent very valuable tools in chemistry and biology.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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